London was still recovering from the Great Plague less than a year earlier when the Fire of London broke out.
The plague started in Drury Lane in December 1664. A small number died of plague during the winter but then in the week of 19 April 1665, three deaths were reported in the parish of St Giles-in-the-Fields outside the City walls. From then on the death toll rose as the disease spread swiftly through London.
The worst hit parishes were those in poorer areas outside the City, such as Southwark and Whitechapel. The rich, the court and many clergy and doctors had escaped London, leaving the poor to face the plague. By the end of July over 1,000 people were dying each week, and in September more than 7,000 people died in one week alone.
From October 1665, the disease began to lessen and people gradually returned to London. In total, around 100,000 people had died.